The pathology of inflammatory diseases such as psoriasis, rheumatoid arthritis and multiple sclerosis is driven by several pro-inflammatory cytokines, including IL-17A, IL-17F, IL-21, TNF and interferon, which are produced by specific T helper cells (Th17/Th1). Mission has identified potent and selective small molecule inhibitors against the de-ubiquitylating enzyme Cezanne-1, which demonstrate strong inhibition of Th17/Th1 cells.
Inhibition of Cezanne-1 potentially represents a novel first-in-class small molecule approach for specifically targeting inflammatory disease.
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