MISSION Therapeutics receives funding from Innovate UK for DUB cancer programme

CAMBRIDGE, UK – 22 September 2015 MISSION Therapeutics, a drug discovery and development company focused on selectively targeting deubiquitylating enzymes to treat cancer and other diseases, today announced that it has been awarded a £1.9 million grant from Innovate UK. The funding is for the discovery of preclinical DUB inhibitors directed at specific deubiquitylating enzymes (DUBs).

DUBs are involved in multiple cellular processes, including DNA damage and cell proliferation, and the inhibition of these enzymes has considerable potential for the generation of novel drugs for treating cancer and other unmet medical needs.

“This funding support from Innovate UK is further validation of our DUB technology platform and science. It will help us develop our pipeline and establish MISSION Therapeutics as a World-leader in the DUB field. More importantly, it will enable us to expand our search for new solutions to treat life-threatening diseases such as cancer”, commented Anker Lundemose, Chief Executive Officer, MISSION Therapeutics.

MISSION Therapeutics has received funding from the eighth round of the Biomedical Catalyst (BMC), a joint programme run by the Medical Research Council and the government’s innovation experts: Innovate UK (IUK). This fund supports UK academics and small to medium-sized businesses seeking to take their research from discovery through to commercialisation to deliver patient benefit.

DUBs are increasingly being considered as attractive therapeutic targets due to their relevance to many diseases such as cancer, inflammation, neurodegeneration, muscle wasting and infectious disease. However, despite significant efforts within the pharmaceutical sector, there is a lack of DUB inhibitors in clinical development. MISSION Therapeutics is a World-leading expert in DUB drug discovery with the scientific know-how to produce multiple DUB inhibitors as viable drug candidates. In this Innovate UK-funded project, MISSION will use its proprietary and unique technology platform to identify novel chemical entities targeting a particular DUB that lies at a key node of oncogenic signaling. Ultimately, these inhibitors, with first-in-class potential, will be used for treating malignancies with high unmet need for the benefit of cancer sufferers worldwide.

CONTACT:

MISSION Therapeutics Ltd
Anker Lundemose MD PhD
Chief Executive Officer
Tel +44 1223 497454

Hume Brophy
Mary Clark, Eva Haas, Hollie Vile
Email: missiontherapeutics@humebrophy.com
Tel: +44 2034 405654

NOTES TO EDITORS:

About MISSION Therapeutics
MISSION Therapeutics was founded in 2011 to commercialise expert research into the ubiquitin pathway for the treatment of cancers and other diseases of unmet need. It has built a World-leading platform for the discovery and development of first-in-class, small molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging, and hitherto intractable, drug class that is attracting significant commercial interest as the potential ‘Next Kinase Area’.
MISSION’s leadership team has a wealth of international, commercial and scientific experience and the company has strong links with key academic and research centers including Cancer Research UK laboratories and the Jackson Laboratories at the Gurdon Institute, University of Cambridge.
The Company has received £27 million in venture capital from a blue chip syndicate comprising institutional (Sofinnova Partners, Imperial Innovations) and corporate (SR One, Roche Venture Fund and Pfizer) investors and is based at the Babraham Research Campus, south of Cambridge.
About Innovate UK
Innovate UK is the UK’s innovation agency. It works with people, companies and partner organisations to find and drive the science and technology innovations that will grow the UK economy. For more details please visit www.innovateuk.gov.uk

MISSION Therapeutics appoints Michael Koslowski as Chief Medical Officer

CAMBRIDGE, UK – 1 September 2015MISSION Therapeutics (MISSION), a drug discovery and development company focused on selectively targeting deubiquitylating enzymes to treat cancer and other diseases, today announced the appointment of Dr Michael Koslowski as Chief Medical Officer to take effect from 1 September 2015.

Dr Koslowski brings over 15 years’ experience across biopharmaceutical research and development, specialising in drug target discovery and clinical validation. Dr Koslowski joins MISSION from Glenmark Pharmaceuticals where he served as Head of Clinical Sciences & Early Development and led Glenmark’s first oncology development programme. Prior to this, Dr Koslowski was Global Head of Translational Medicine Experts at Boehringer Ingelheim, where he had oversight of the transition of projects and programmes across all therapeutic areas, from early research through to clinical proof of concept.

Commenting on the appointment, Dr Anker Lundemose, Chief Executive Officer of MISSION Therapeutics, said: “We are very pleased to welcome Dr Koslowski to MISSION’s senior management team. His track record and expertise in successfully translating research into the clinic will enable us to further advance our proprietary DUB platform, and develop new classes of medicines in cancer as well as other disease areas with high unmet medical need. This appointment supports MISSION’s growth strategy as we continue to transition our business into a clinical stage organisation. We look forward to benefiting from Dr Koslowski’s experience and in-depth knowledge of clinical development.”

Dr Michael Koslowski, newly appointed Chief Medical Officer of MISSION Therapeutics, added:MISSION has developed a proprietary and world-class technological and transferable expertise in developing DUB inhibitors. I am thrilled to join this highly experienced team in progressing the potential of the Company’s platform.”

Prior to Boehringer Ingelheim, Dr Koslowski was Associate Professor of Molecular Medicine at the University of Mainz. He is also founding member and former Group Head, New Targets & Antibody Development, Ganymed Pharmaceuticals AG, a spin-off from the Universities of Mainz and Zürich. While at Ganymed Pharmaceuticals AG, Dr Koslowski implemented a sustainable target discovery platform, one of the cornerstones for the foundation of the Company. Dr Koslowski was Principal Scientist in Experimental and Translational Oncology at the University of Mainz from 2000 to 2010, and a research scientist in Target Discovery and Research at University of the Saarland in Hamburg.

CONTACT:

MISSION Therapeutics Ltd

Anker Lundemose MD PhD

Chief Executive Officer

Tel +44 1223 497454

Hume Brophy

Mary Clark, Eva Haas, Hollie Vile

Email: missiontherapeutics@humebrophy.com

Tel: +44 203 440 5654

NOTES TO EDITORS:

About MISSION Therapeutics

MISSION Therapeutics was founded in 2011 to commercialise expert research into the ubiquitin pathway for the treatment of cancers and other diseases of unmet need. It has built a World-leading platform for the discovery and development of first-in-class, small molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging, and hitherto intractable, drug class that is attracting significant commercial interest as the potential ‘Next Kinase Area’.

MISSION’s leadership team has a wealth of international, commercial and scientific experience and the Company has strong links with key academic and research centres including Cancer Research UK laboratories and the Jackson Laboratories at the Gurdon Institute, University of Cambridge.

The Company has received £27 million in venture capital from a blue chip syndicate comprising institutional (Sofinnova Partners, Imperial Innovations) and corporate (SR One, Roche Venture Fund and Pfizer) investors and is based at the Babraham Research Campus, south of Cambridge.

MISSION appoints Dr Colin Goddard to its Board of Directors

CAMBRIDGE, UK,  1ST JULY 2015 – MISSION Therapeutics, a drug discovery and development company today announced Dr Colin Goddard, former Chief Executive Officer of OSI Pharmaceuticals (“OSI”), has been appointed to the Company’s Board of Directors.

“We are privileged to have Dr Goddard join our board at this exciting phase of MISSION’s growth and development”, commented Michael Moore, Chairman, MISSION Therapeutics.

“Dr Goddard has more than 25 years of outstanding leadership experience in the US biopharmaceutical industry and will add a complementary strategic dimension to our board. We look forward to benefiting from his corporate vision, as we continue to transition our business into a clinical stage organisation.”

Dr Anker Lundemose, Chief Executive Officer of MISSION Therapeutics added: “We are pleased to welcome Dr Goddard to MISSION Therapeutics. His experience and track record in clinical development will be invaluable as we look to develop new drugs that will significantly improve the management of cancer.”

Dr Goddard joined OSI as a research scientist in 1989 and led the transformation of the technology platform services company into a profitable fully integrated biopharmaceutical organisation, becoming CEO in 1998. He was pivotal in the registration and launch of OSI’s targeted therapeutic product, Tarceva (erlotinib) and also directed the Company’s financing, corporate development and acquisition strategies, completing several major acquisitions and divestitures and raising over $1.5bn in capital. OSI was acquired by Astellas Pharma Inc. in June 2010 for $4bn.

Dr Goddard obtained his PhD in cancer pharmacology from the University of Aston in Birmingham, UK and worked at the National Cancer Institute, Bethesda, MD, before joining OSI. He currently serves as Executive Chairman of US based Biotech companies, Coferon, Inc and Merganser Biotech and as a Director on the boards of Endocyte Inc (NASDAQ: ECYT) and PanOptica Inc.; He was formerly a Director at Human Genome Sciences Inc.

About MISSION Therapeutics

Founded in 2011, MISSION Therapeutics builds on the research of Professor Steve Jackson FRS, who holds the Frederick James Quick Chair of Biology at the University of Cambridge, by exploiting the new and extensive research emerging on the ubiquitin pathways that control cellular responses to DNA damage.

MISSION has established a broad platform of technologies for the discovery and preclinical development of first-in-class modulators of ubiquitin pathway enzymes involved in cancer and other diseases. The Company is developing drugs to inhibit the proliferation of tumour cells, exploiting certain properties of specific DUBs, such as their oncogene status or association with synthetic lethality, the latter now a clinically-proven mechanism for selectively killing tumour cells.

The Company has received £27 million in venture capital from a blue chip syndicate comprising institutional (Sofinnova Partners, Imperial Innovations) and corporate (SR One, Roche Venture Fund and Pfizer) investors and is based at the Babraham Research Campus, south of Cambridge.

CONTACT:

MISSION Therapeutics Ltd

Anker Lundemose MD PhD

Chief Executive Officer

Tel +44 1223 497454

Hume Brophy

Mary Clark, Hollie Vile, Alexia Faure

Email: missiontherapeutics@humebrophy.com

Tel: +44 2034 405654

Prof Steve Jackson to give Sackler Lecture

Professor Steve Jackson, MISSION Therapeutics CSO and Professor of Biology, Head of Cancer Research UK laboratories at the Gurdon Institute, University of Cambridge, will be giving the 22nd Raymond and Beverly Sackler distinguished lecture on the 11th of June in Leeds and on the 25th of June in Cambridge. The title of the lecture is ‘Cellular responses to DNA damage:mechanistic insights and new cancer therapies’.

MISSION Therapeutics presents at AACR the identification of novel inhibitors of the UCHL1 oncogene

Cambridge UK, 20 April 2015 – MISSION Therapeutics, a company focused on the discovery and development of modulators of the deubiquitylating (DUB) enzyme family for the treatment of cancer and other diseases, today presents a poster at AACR entitled “Discovery of highly selective UCHL1 inhibitors with in vivo pre-clinical anti-tumour activity”.

UCHL1 is a prototypical oncogene that selectively drives proliferation in many tumour types including multiple myeloma and lung cancer. UCHL1 depletion leads to the selective killing of a number of tumours whose proliferation is driven by UCHL1. Validation of DUB targets like UCHL1 exemplifies the rationale for developing inhibitors of the ubiquitin pathways to target a broad range of cancers with defined genetic abnormalities, or resistance to standard-of-care modalities. Using its integrated drug discovery platform combining unique biochemical, cellular, biophysical and structural assays,MISSION has identified and optimised potent and selective small molecule, active site inhibitors of UCHL1. These inhibitors recapitulate UCHL1 target biology and exhibit in vitro target engagement in proprietary cellular assays. Further lead optimisation has generated compounds with drug-like properties that demonstrate efficacy in disease models. Cumulatively, the data support not only the potential further pre-clinical development of UCHL1 compounds but also the tractability of a broader range of DUBs to pharmacologic intervention, with the potential to reach a diversity of cancers comprising different genetic signatures.

Xavier Jacq, Vice President Biology at MISSION, commented: “We are delighted to share our recent progress in the development of first-in-class selective UCHL1 inhibitors targeting difficult to treat cancers. The advances presented, underpin MISSION’s ability to identify small molecule leads of a hitherto difficult enzyme class. Surmounting the key challenges of targeting DUBs, we have paved the way for the timely development of inhibitors of several DUBs and the generation of a wholly new structural class of anti-cancer agents”.

About MISSION Therapeutics
Founded in 2011, MISSION Therapeutics builds on the research of Professor Steve Jackson FRS, who holds the Frederick James Quick Chair of Biology at the University of Cambridge, by exploiting the new and extensive research emerging on the ubiquitin pathways that control cellular responses to DNA damage.

MISSION has established a broad platform of technologies for the discovery and preclinical development of first-in-class modulators of ubiquitin pathway enzymes involved in cancer and other diseases. The Company is developing drugs to inhibit the proliferation of tumour cells, exploiting certain properties of specific DUBs, such as their oncogene status or association with synthetic lethality, the latter now a clinically-proven mechanism for selectively killing tumour cells.

The Company has received £27 million in venture capital from a blue chip syndicate comprising institutional and corporate investors (Sofinnova Partners, Imperial Innovations, SR One, Roche Venture Fund and Pfizer Venture Investments) and is based at the Babraham Research Campus, south of Cambridge.

CONTACT:
MISSION Therapeutics Ltd
Dr Anker Lundemose, Chief Executive Officer
+44 (0)1223 497197
Email: enquiries@missiontherapeutics.com

Instinctif Partners
Tim Watson
+44 (0)20 7866 7861
Email: missiontherapeutics@instinctif.com

MISSION Therapeutics wins new Life Science Innovation Award

Recognition of outstanding progress in hitherto challenging therapeutic target area

Cambridge UK, 20 March 2015 – MISSION Therapeutics, a company focused on the discovery and development of modulators of the deubiquitylating (DUB) enzyme family for the treatment of cancer and other diseases, today announces that it has won the new Life Science Innovation Award at the 25th Anniversary Business Weekly Awards ceremony.

The award was accepted by Professor Steve Jackson, CSO at MISSION, at an awards dinner at Queen’s College, Cambridge on behalf of the Company, which was judged to have done most in the region to further the cause of life science discovery for the benefit of human healthcare. AstraZeneca and MedImmune, as sponsors of the Award, spearheaded the judging for the category, with AZ dealmaker, Shaun Grady, and MedImmune’s site leader in Cambridge, Jane Osbourn, as the judges.

The Business Weekly Awards attracts entries from across the East of England and is the longest-running B2B competition in the UK. Now in its 25th year, the Awards pride themselves on early identification of world-leading businesses. To mark the 25th anniversary, the awards categories were finessed to reflect the expansion of the region since the awards began, with eight award categories “up for grabs” including Start-up of the Year, International Trade Champion and Wireless Innovation.

Commenting on the award, CEO Anker Lundemose said: “To receive recognition from one’s peers is hugely gratifying. It is a credit to the team at MISSION that they have developed a highly promising pipeline of drug candidates in recent years, not just in our primary area of focus, cancer, but also a wider range of indications. Having recently joined the team, I am personally excited to be playing a lead role in advancing key assets from MISSION’s pipeline into the clinic, independently and through selective partnering.”
About MISSION Therapeutics

Founded in 2011, MISSION Therapeutics builds on the research of Professor Steve Jackson FRS, who holds the Frederick James Quick Chair of Biology at the University of Cambridge, by exploiting the new and extensive research emerging on the ubiquitin pathways that control cellular responses to DNA damage.

MISSION has established a broad platform of technologies for the discovery and preclinical development of first-in-class modulators of ubiquitin pathway enzymes involved in cancer and other diseases. The Company is developing drugs to inhibit the proliferation of tumour cells, exploiting certain properties of specific DUBs, such as their oncogene status or association with synthetic lethality, the latter now a clinically-proven mechanism for selectively killing tumour cells.

The Company has received £27 million in venture capital from a blue chip syndicate comprising institutional and corporate investors (Sofinnova Partners, Imperial Innovations, SR One, Roche Venture Fund and Pfizer Venture Investments) and is based at the Babraham Research Campus, south of Cambridge.
CONTACT:
MISSION Therapeutics Ltd
Dr Anker Lundemose, Chief Executive Officer
+44 (0)1223 497197
Email: enquiries@missiontherapeutics.com

Instinctif Partners
Tim Watson
+44 (0)20 7866 7861
Email: missiontherapeutics

MISSION appoints Paul Wallace as Chief Business Officer

Appointment highlights scope and productivity of drug discovery platform

Cambridge UK, 16 March 2015 – MISSION Therapeutics, a company focused on the discovery and development of modulators of the deubiquitylating (DUB) enzyme family for the treatment of cancer and other diseases, announces the appointment of Paul Wallace PhD as Chief Business Officer.

Dr Wallace joins MISSION to formulate future business strategy at a time when the Company’s pipeline has matured to the point where strategic options such as development partnerships are ready to be explored. Having worked in business development roles within drug discovery companies for nearly 20 years, Dr Wallace was most recently Executive Vice President and Head of Business Development at Medivir AB, where he was also a member of the Executive Management Team responsible for strategic and operational leadership, R&D portfolio management and investment planning. During this time he was central to the execution of more than 25 partnership deals, 8 products were taken into clinical development, 2 drugs were launched and Medivir transitioned into a profitable pharmaceutical company. Prior to his roles in business development Dr Wallace had a career in pharmaceutical research and undertook his PhD and post-doctoral studies at the University of Cambridge.

Anker Lundemose, MISSION Chief Executive Officer commented: “With MISSION currently embarking on the preclinical development of its lead molecules, Paul’s extensive business development experience will be invaluable in helping us find the right strategic partnerships to fully realise the potential of these assets. Our core focus is cancer, but our platform discovery approach has yielded highly promising molecules for other indications, such as Parkinson’s disease. We see partnering as an attractive option for taking these non-core projects forward.”

Paul Wallace responded: “I am delighted to be joining the MISSION team at a time when the commercialisation of certain of its assets is an increasingly promising prospect. The Company’s progress in unlocking successive DUB targets to potent and selective small molecule inhibitors positions MISSION for entering partnership transactions outside its proprietary oncology programs. The diversity of assets created is testimony to the rigour of MISSION’s screening platform in this critically important, but hitherto difficult, area of drug discovery”.

About MISSION Therapeutics
Founded in 2011, MISSION Therapeutics builds on the research of Professor Steve Jackson FRS, who holds the Frederick James Quick Chair of Biology at the University of Cambridge, by exploiting the new and extensive research emerging on the ubiquitin pathways that control cellular responses to DNA damage.

MISSION has established a broad platform of technologies for the discovery and preclinical development of first-in-class modulators of ubiquitin pathway enzymes involved in cancer and other diseases. The Company is developing drugs to inhibit the proliferation of tumour cells, exploiting certain properties of specific DUBs, such as their oncogene status or association with synthetic lethality, the latter now a clinically-proven mechanism for selectively killing tumour cells.

The Company has received £27 million in venture capital from a blue chip syndicate comprising institutional and corporate investors (Sofinnova Partners, Imperial Innovations, SR One, Roche Venture Fund and Pfizer Venture Investments) and is based at the Babraham Research Campus, south of Cambridge.

CONTACT:
MISSION Therapeutics Ltd
Dr Anker Lundemose, Chief Executive Officer
+44 (0)1223 497197
Email: enquiries@missiontherapeutics.com

Instinctif Partners
Tim Watson
+44 (0)20 7866 7861
Email: missiontherapeutics@instinctif.com

MISSION appoints Anker Lundemose as Chief Executive Officer

Appointment strengthens UK drug discovery team for transformational change.

Cambridge, UK – 9 January 2015 – MISSION Therapeutics, a company focused on the discovery and development of modulators of the deubiquitylating (DUB) enzyme family for the treatment of cancer and other diseases, announces the appointment of Dr Anker Lundemose MD PhD as Chief Executive Officer.

Dr Lundemose brings extensive experience to MISSION at a pivotal stage in the Company’s evolution, as it transitions from discovery to development. In a biopharma career spanning over two and a half decades, he was most recently CEO of Norwegian vaccine company Bionor Pharma ASA, and previously co-founder and CEO of Prosidion, the UK spin-out of OSI Pharmaceuticals’ diabetes and obesity assets, subsequently reversed into OSI.  The MISSION appointment constitutes Dr Lundemose’s fourth CEO position. As a CEO, Executive Vice President, co-founder and/or board member, he has been involved in a total of six biotech exits/IPOs.

Michael Moore, MISSION Executive Chairman, commented: “On behalf of the board and management I am delighted to welcome Anker at this exciting time for the Company, as it embarks on the preclinical development of its lead molecules. His extensive drug translational and business development experience across several therapeutic areas, among his other corporate credentials, will catalyze our transition from discovery to development and maximise the commercial horizons of the Company.”

Anker Lundemose commented: “I am thrilled to be joining MISSION at this transitional stage of the Company’s development.  MISSION clearly has the opportunity to become the world’s premier DUB R&D company given the world-class standing of its science, the track record of its management and the vision of its investor syndicate. I look forward to working with management and investors alike to build on the asset value already created by the MISSION team.”

– ENDS –

Notes To Editors

About MISSION Therapeutics

Founded in 2011, MISSION Therapeutics builds on the research of Professor Steve Jackson FRS, who holds the Frederick James Quick Chair of Biology at the University of Cambridge, by exploiting the new and extensive research emerging on the ubiquitin pathways that control cellular responses to DNA damage.

MISSION has established a broad platform of technologies for the discovery and preclinical development of first-in-class modulators of ubiquitin pathway enzymes involved in cancer and other diseases. The Company is developing drugs to inhibit the proliferation of tumour cells, exploiting certain properties of specific DUBs, such as their oncogene status or association with synthetic lethality, the latter now a clinically-proven mechanism for selectively killing tumour cells.

The Company has received £27 million in venture capital from a blue chip syndicate comprising institutional and corporate investors (Sofinnova Partners, Imperial Innovations, SR One, Roche Venture Fund and Pfizer Venture Investments) and is based at the Babraham Research Campus, south of Cambridge.

MISSION was assisted in the recruitment of Dr Lundemose by Russell Reynolds Associates
Issued for and on behalf of MISSION Therapeutics by Instinctif Partners.
For more information please contact:

MISSION Therapeutics Ltd

Dr Michael Moore, Executive Chairman
+44(0)7909 090887

Dr Niall Martin, Chief Operating Officer
+44(0)1223 497451
Email: enquiries@missiontherapeutics.com

Instinctif Partners
Tim Watson
+44(0)20 7866 7861
Email: MissionTherapeutics@instinctif.com