CAMBRIDGE, UK– 15 March 2021 – Mission Therapeutics (“Mission”), a drug discovery and development company focused on selectively inhibiting deubiquitylating enzymes (DUBs), has announced today that Paul Thompson, Chief Scientific Officer, will present at the Targeted Protein Degradation Europe Summit (16-18 March).

Paul Thompson will present on 18 March at 14:05 GMT, discussing how deubiquitylating (DUB) enzymes can be targeted for the treatment of human diseases. As an example, Paul will examine Mission’s lead in-house DUB inhibitor target, USP30.

The Targeted Protein Degradation Europe Summit was created with the goal of accelerating the translation of selective bioavailable and effective protein degraders into clinical trials. The Summit provides a platform of learning, discovery, and networking opportunities, to hear about the latest developments and advancements, and get invaluable guidance from leaders in the field of protein degradation. The event brings together over 100 biopharmaceutical professionals to capitalise on this emerging therapeutic class and make targeted protein degradation a blockbuster therapeutic approach that improves patient outcomes.

FOR MORE INFORMATION:

Mission Therapeutics Ltd
Anker Lundemose MD PhD
Chief Executive Officer
Tel: +44 (0)1223 607 340

Instinctif Partners
Melanie Toyne-Sewell / Katie Duffell
Tel: +44 (0) 20 7457 2013
missiontherapeutics@instinctif.com

NOTES TO EDITORS:

About Mission Therapeutics

Mission Therapeutics is an early-stage drug development company targeting the ubiquitin pathway for the treatment of kidney disease, neurodegenerative disease, rare mitochondrial diseases and fibrosis. The Company has built a leading platform for the discovery and development of first-in-class, small molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging drug class that is attracting significant commercial interest in the area of protein homeostasis.

Mission has strong links with key academic and research centers, including Prof. Steve Jackson’s Cancer Research UK Laboratories at the University of Cambridge Gurdon Institute, and leading UK centres in neurodegenerative diseases. The Company also has secured major industry partnerships, including its collaboration with AbbVie in November 2018, for the research and preclinical development of specified DUB inhibitors for the treatment of Alzheimer’s Disease and Parkinson’s Disease. The Company is managed by a team with broad international, commercial and clinical-science experience.

To date the Company has received £73 million /$101 million in funding and its investors comprise blue chip institutional and corporate investors including: Pfizer Venture Investments, Sofinnova Partners, Roche Venture Fund, SR One, IP Group and Schroder Adveq. Mission Therapeutics was founded in 2011 and is based at the Babraham Research Campus, Cambridge, UK.

For more information, please visit our website, www.missiontherapeutics.com, or follow us on Twitter or LinkedIn.

CAMBRIDGE, UK– 2 November 2020 – Mission Therapeutics, a drug discovery and development company focused on selectively inhibiting deubiquitylating enzymes (DUBs), has appointed Dr Suhail Nurbhai as Chief Medical Officer (CMO) with immediate effect.

Dr Nurbhai has more than 25 years of experience and a strong track record in the strategic and operational leadership of all phases of clinical research and development at companies across Europe and the US. He joins Mission from VHsquared, where he held the position of CMO since 2014.

Prior to VHsquared, Suhail was Senior Vice President and Head of Development and Medical Affairs for Shionogi in Europe. He joined Shionogi from Takeda where he was Vice President and Head of Clinical and Analytical Science in Europe, with responsibility for all Clinical Science activities in Neurosciences, Cardiovascular/Renal/Metabolic, Oncology, Gastrointestinal/Genitourinary and Respiratory Medicine, as well as Clinical Pharmacology, Medical Writing, Statistics and Data Management.

Suhail’s initial industry experience was at Pfizer, where he spent 12 years, initially in Sandwich, UK and then at Global R&D Headquarters in Connecticut, USA. During his time at Pfizer he held roles of increasing responsibility across multiple therapeutic areas including GI/GU, anti-bacterial, sexual medicine and anti-fungal, prior to completing his time at Pfizer as Head of Neuroscience Clinical R&D at the Groton site in Connecticut.

During his career he has led teams bringing multiple compounds from pre-clinical phase into clinical studies in both Europe and US, and achieved multiple successful NDA and MAA submissions and approvals.

Suhail qualified in Medicine at Dundee University in Scotland and completed his post-graduate medical training at Hope Hospital in the University of Manchester.

Commenting on the appointment, Dr Anker Lundemose, CEO of Mission Therapeutics said: “We are pleased to be welcoming Suhail to further strengthen Mission’s leadership team. His in-depth knowledge and proven track record in clinical research will be invaluable as we work to bring our first-in-class USP30 inhibitor compound into the clinic. Suhail’s appointment is the last of a series of organisational changes, including the promotions of Dr Paul Thompson and Dr Nick Edmunds, to ready the Company for this next phase.”

Dr Suhail Nurbhai added: “It’s great to be joining Mission at such an exciting time for the Company. The ongoing collaboration with AbbVie and recently signed agreement with Pfizer represent solid industry validation of the Company’s approach and ground-breaking technology. I look forward to building on this success progressing its lead assets into the clinic.”

Dr Suhail Nurbhai. High-resolution images available on request.

FOR MORE INFORMATION:

Mission Therapeutics Ltd
Anker Lundemose MD PhD
Chief Executive Officer
Tel: +44 (0)1223 607 340

Instinctif Partners
Melanie Toyne-Sewell / Katie Duffell
Tel: +44 (0) 20 7457 2013
missiontherapeutics@instinctif.com

NOTES TO EDITORS:

About Mission Therapeutics

Mission Therapeutics is an early-stage drug development company targeting the ubiquitin pathway for the treatment of kidney disease, neurodegenerative disease, rare mitochondrial diseases and fibrosis. The Company has built a leading platform for the discovery and development of first-in-class, small molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging drug class that is attracting significant commercial interest in the area of protein homeostasis.

Mission has strong links with key academic and research centers, including Prof. Steve Jackson’s Cancer Research UK Laboratories at the University of Cambridge Gurdon Institute, and leading UK centres in neurodegenerative diseases. The Company also has secured major industry partnerships, including its collaboration with AbbVie in November 2018, for the research and preclinical development of specified DUB inhibitors for the treatment of Alzheimer’s Disease and Parkinson’s Disease. The Company is managed by a team with broad international, commercial and clinical-science experience.

To date the Company has received £73 million /$101 million in funding and its investors comprise blue chip institutional and corporate investors including: Pfizer Venture Investments, Sofinnova Partners, Roche Venture Fund, SR One, IP Group and Schroders Adveq. Mission Therapeutics was founded in 2011 and is based at the Babraham Research Campus, Cambridge, UK.

For more information, please visit our website, www.missiontherapeutics.com, or follow us on Twitter or LinkedIn.

LONDON AND CAMBRIDGE, UK – 7 July 2020 – Working in close collaboration, scientists from the Tate Group, Imperial College London, and drug discovery and development company, Mission Therapeutics (“Mission”), have discovered the first exquisitely selective probe for a deubiquitylating enzyme (DUB). The research has been published in the leading peer-reviewed Journal of the American Chemical Society (JACS).¹

In this publication, Mission and the Tate Group report discovery of IMP-1710, a potent and selective activity-based probe for DUB UCHL1. Outstanding selectivity was demonstrated against a broad panel of other DUBs and confirmed through proteomic profiling. Such high quality, selective chemical probes can be powerful tools in unveiling novel biology and enabling research into new potential therapeutic targets.

With numerous links to disease pathologies, DUBs have attracted increasing interest as possible drug targets. DUBs are responsible for reversibly modifying proteins by removing ubiquitin ‘labels’. Over 100 human DUBs have been identified, expressed in many different cell types, with multiple different functions including regulating degradation of other proteins.

The UCHL1 DUB makes up over 1% of the protein mass of the human brain and is thought to play an important role in diseases including neurodegeneration, cancer and fibrosis. To-date, scientists have struggled to understand how UCHL1 works and how it drives disease because there is no effective inhibitor probe with which to study it.

As a selective UCHL1 probe, IMP-1710 provides researchers with the necessary tool to enable substantial progress in the field. In this study, the probe has already been used to inhibit and measure UCHL1 activity inside a range of cells for the first time. In cells from patients with idiopathic pulmonary fibrosis, IMP-1710 was shown to suppress activation of fibrosis pathways.

Commenting on the achievement, Prof. Edward Tate, Professor of Chemical Biology, Imperial College London, and Satellite Group Leader, Francis Crick Institute, said: “IMP-1710 represents a great leap forward both for UCHL1 research and for DUB programmes more broadly. Mission’s world-leading DUB platform has been fundamental to the success of the project. Together, we have reported the first potent and exquisitely selective activity-based probe for any DUB. This probe promises to unlock a new era of discovery for the important UCHL1 protein.”

Dr. Nick Edmunds, Vice President, Head of DUB Discovery at Mission, added: “This publication is the result of a long-term collaboration between Mission and Imperial. It is tremendous to report the research in such a high impact journal. This is a credit to the quality and significance of the science, as well as the dedication of the teams involved. The novel chemical probe will support and drive ongoing research towards treating fibrosis and other diseases with high unmet need.”

References
1. Panyain N, Godinat A, Lanyon-Hogg T, Lachiondo-Ortega S, Will EJ, Soudy C, Mondal M, Mason K, Elkhalifa S, Smith LM, Harrigan JA, and Tate EW. Discovery of a potent and selective covalent inhibitor and activity-based probe for the deubiquitylating enzyme UCHL1, with anti-fibrotic activity. J. Am. Chem. Soc., 2020;
https://doi.org/10.1021/jacs.0c04527/a>

– ENDS –

FOR MORE INFORMATION:

Mission Therapeutics Ltd
Anker Lundemose MD PhD
Chief Executive Officer
Tel: +44 (0)1223 607 340

Instinctif Partners
Melanie Toyne-Sewell / Katie Duffell
Tel: +44 (0) 20 7457 2013
missiontherapeutics@instinctif.com

NOTES TO EDITORS:

About Mission Therapeutics

Mission Therapeutics is an early-stage drug development company targeting the ubiquitin pathway for the treatment of kidney disease, neurodegenerative disease, rare mitochondrial diseases and fibrosis. The Company has built a leading platform for the discovery and development of first-in-class, small molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging drug class that is attracting significant commercial interest in the area of protein homeostasis.

Mission has strong links with key academic and research centers, including Prof. Steve Jackson’s Cancer Research UK Laboratories at the University of Cambridge Gurdon Institute, and leading UK centres in neurodegenerative diseases. The Company also has secured major industry partnerships, including its collaboration with AbbVie in November 2018 for the research and preclinical development of specified DUB inhibitors for the treatment of Alzheimer’s Disease and Parkinson’s Disease. The Company is managed by a team with broad international, commercial and clinical-science experience.

To date the Company has received £73 million / $101 million in funding. Its investors comprise blue chip institutional and corporate investors including: Pfizer Ventures, Sofinnova Partners, Roche Venture Fund, SR One, IP Group and Schroders Adveq. Mission Therapeutics was founded in 2011 and is based at the Babraham Research Campus, Cambridge, UK.

For more information, please visit our website, www.missiontherapeutics.com, or follow us on Twitter or LinkedIn.

About Imperial College London

Imperial College London is one of the world’s leading universities. The College’s 17,000 students and 8,000 staff are expanding the frontiers of knowledge in science, medicine, engineering and business, and translating their discoveries into benefits for our society.

Imperial is the UK’s most international university, according to Times Higher Education, with academic ties to more than 150 countries. Reuters named the College as the UK’s most innovative university because of its exceptional entrepreneurial culture and ties to industry.

www.imperial.ac.uk

For more information on the Tate Group, visit: www.imperial.ac.uk/tate-group

CAMBRIDGE, UK – 2 June 2020 – Mission Therapeutics (“Mission”), a drug discovery and development company focused on selectively inhibiting deubiquitylating enzymes (DUBs), today announces its move to new purpose-built headquarters on the Babraham Research Campus, Cambridge, UK.

Since its foundation in 2011, Mission has enjoyed significant success in building its world-leading DUB platform for the discovery and development of first-in-class, small molecule drugs. It has a thriving pipeline of programs in neurodegeneration, rare mitochondrial diseases, kidney disease and fibrosis, in-house and in partnership with a major biopharmaceutical company, AbbVie.

As the Company has grown, its need for space has increased and it has had to split its operations across two sites – at Granta Park and the Babraham Research Campus. Mission’s move into BioMed Realty’s newly developed Babraham Research Campus buildings will combine its two existing sites. This will bring all employees back together, promoting collaboration, innovation and efficiency, and will provide 40% more space to facilitate the Company’s continuing growth.

Mission anticipates completing the move of its offices and research laboratories into the new facility by 8 June 2020.

Commenting on the move, Dr. Anker Lundemose, Mission’s CEO said:
“With Mission’s strong growth outlook, this move to a new, larger, united facility is key to our strategy. These headquarters will provide an inspiring work environment and support our culture of innovation and collaboration. We are happy to be staying on the Babraham Research Campus, which we have found offers an extraordinary ecosystem, with world-class research and business coming together.

“On behalf of the management team, I would like to thank everyone, from both within and outside the Company, who has helped to execute this move so successfully. It has required a great feat of organisation, particularly during these unprecedented times under COVID-19 disruption. We are looking forward to all being together again.”

– ENDS –

FOR MORE INFORMATION:

Mission Therapeutics Ltd
Anker Lundemose MD PhD
Chief Executive Officer
Tel: +44 (0)1223 607 340

Instinctif Partners
Melanie Toyne-Sewell / Katie Duffell
Tel: +44 (0) 20 7457 2013
missiontherapeutics@instinctif.com

NOTES TO EDITORS:

About Mission Therapeutics

Mission Therapeutics is an early-stage drug development company targeting the ubiquitin pathway for the treatment of kidney disease, neurodegenerative disease, rare mitochondrial diseases and fibrosis. The Company has built a leading platform for the discovery and development of first-in-class, small molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging drug class that is attracting significant commercial interest in the area of protein homeostasis.

Mission has strong links with key academic and research centers, including Prof. Steve Jackson’s Cancer Research UK Laboratories at the University of Cambridge Gurdon Institute, and leading UK centres in neurodegenerative diseases. The Company has also secured major industry partnerships, including its collaboration with AbbVie, which began in November 2018, for the research and preclinical development of specified DUB inhibitors for the treatment of Alzheimer’s Disease and Parkinson’s Disease. The Company is managed by a team with broad international, commercial and clinical-science experience.

To date, the Company has received £61 million ($86 million) in funding from blue chip institutional and corporate investors including: Pfizer Venture Investments, Sofinnova Partners, Roche Venture Fund, SR One, IP Group and Schroder Adveq. Mission Therapeutics was founded in 2011 and is based at the Babraham Research Campus, Cambridge, UK.

For more information, please visit our website, www.missiontherapeutics.com, or follow us on Twitter or LinkedIn.

Set to open in April 2020, the buildings are now more than 50% let or under offer, highlighting the thriving life science industry in Cambridge

Today, BioMed Realty, the leading provider of real estate solutions to the life science community, announced its two newly developed Babraham Research Buildings in Cambridge are more than 50% let or under offer, including leases to PetMedix Ltd and Mission Therapeutics Ltd.

In October 2017, BioMed Realty and Babraham Research Campus launched a partnership, creating 100,000 square foot of research space for growing bioscience-based companies seeking to scale up their operations. BioMed@Babraham encompasses two adjacent buildings and the new facilities will provide a corporate campus feel to further promote innovation and strengthen links between academia and the commercial world. This project represents a £42 million investment in the Campus by BioMed Realty.

Colleen O’Connor, BioMed Realty’s Senior Director for the UK Market commented: “The Babraham Research Campus has been at the forefront of supporting scale-ups. BioMed@Babraham furthers this effort and offers growing life science companies access to first-class fitted lab and office space within the thriving Babraham Research Campus, which is already home to over 60 research organizations. We are excited to be moving forward on final fit-out construction for all suites, with tenants occupying as early as April 2020.”

As a sector at the cutting edge of science, the leaders of UK life sciences have continued working hard to raise capital for their R&D programmes. The UK BioIndustry Association (BIA) and Informa Pharma Intelligence have released a report showing £182 million was raised by private biotech companies between December 2018 and the end of February 2019, almost £50 million more than during the same period a year earlier.

Dr. Tom Weaver, CEO of PetMedix™ commented: “One of the real strengths of Cambridge for the biotech industry is its ability to both attract large companies and foster the growth of new ones. The ecosystem of academic research, thriving companies, and a highly skilled talent pool make it a perfect place to start and build a company. This success can make it challenging for companies like ours to secure the necessary space to grow in the current competitive commercial environment. PetMedix is entering a growth and expansion phase as we look to bring the power of antibody therapeutics to animal health, and this comes with a need to scale our physical footprint. We are tremendously excited to be one of the first two companies to move into BioMed Reality’s brand new, purpose-built premises on the renowned Babraham campus. BioMed has recognised the clear need for developments of this size and composition, and we are looking forward to establishing PetMedix at this new site and engaging with the vibrant research and development ecosystem of like-minded companies, both at Babraham and in the surrounding Cambridge cluster.”

Michael Jones, Director and Head of Commercial Division for Cheffins Commercial commented: “Life Sciences in the UK continues to thrive, particularly the Cambridge cluster. Babraham offers a rare opportunity to lease new construction with purpose-built life science lab and office space in high-quality buildings. It’s not surprising there is tremendous interest.”

The sector currently contributes over £70 billion to the UK economy and provides jobs for almost 241,000 people across the country. According to data from business intelligence specialist, Vacancysoft, demand for professionals to work within the UK’s Life Sciences sector increased by 11% in 2018 – clinical vacancies rose the highest, with an increase of 37%, and demand for research and development professionals rose by 4.6%.

Dr Anker Lundemose, CEO of Mission Therapeutics added: “Fuelled by its established academic community and growing private sector, Cambridge has a strong science culture, which celebrates entrepreneurship and collaboration. As Mission has prospered and grown over the past seven years, we were forced to split the Company over two sites. The development of these new buildings by BioMed Realty at the Babraham Research Campus present us with the exciting opportunity to bring all our employees together again on one site, to facilitate open collaboration, improve efficiency and promote innovation in the field of mitochondrial diseases, fibrosis and neurodegenerative disorders.”

BioMed Realty entered the Cambridge, UK market with the acquisition of Granta Park in 2012. As part of its continued growth in Cambridge, BioMed Realty formed a collaborative partnership with Babraham Bioscience Technologies in 2017 to build two new buildings on the Babraham Research Campus. Upon completion, the Babraham Research Campus project will bring BioMed Realty’s total presence in Cambridge to almost 900,000 square feet. The addition of BioMed Realty to the Babraham Research Campus supports the Biotechnology and Biological Sciences Research Council’s campus development strategy.

For more information on lettings and the remaining space, please contact Michael Jones, from Cheffins (01223 271971) who are letting agents on behalf of BioMed.

– ENDS –

About BioMed Realty
Founded in 2004, and a Blackstone portfolio company since 2016, BioMed Realty owns and operates high-quality life science real estate comprising 11 million square feet located in the leading innovation markets throughout the United States and United Kingdom, led by Boston-Cambridge, San Francisco, San Diego, Seattle, New York and Cambridge U.K. In addition, BioMed Realty maintains a premier development pipeline with two million square feet of Class A properties in active construction to meet the growing demand of the life science industry. With over 200 tenant partners, BioMed Realty provides real estate solutions for global enterprises, established biotechnology and innovation companies, leading universities and premier research institutions. Follow us on Twitter @biomedrealty.

About PetMedix™
PetMedix™ is a Cambridge, UK based research and development stage biopharmaceutical company developing antibody-based therapeutics for companion animals. The growing team have over 30 years’ experience building platforms that can develop species-specific therapeutic antibodies. Driven by the core value of improving the health and welfare of animals, PetMedix™ is taking the cutting edge of human medicine and using it to develop innovative new veterinary treatments against a wide range of clinical indications for dogs and for cats.
Website: https://www.petmedix.co.uk
Twitter: @PetMedix, LinkedIn: PetMedix, Facebook: @PetMedix, Instagram: @PetMedix

About Mission Therapeutics
Mission Therapeutics is an early-stage drug development company targeting the ubiquitin pathway for the treatment of kidney disease, neurodegenerative disease, rare mitochondrial diseases and fibrosis. The Company has built a leading platform for the discovery and development of first-in-class, small molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging drug class that is attracting significant commercial interest in the area of protein homeostasis. Mission has a collaboration in the research and preclinical development of specified DUB inhibitors for the treatment of Alzheimer’s Disease and Parkinson’s Disease. It also has strong links with academic and research centres, such as Prof. Steve Jackson’s Cancer Research UK Laboratories at the University of Cambridge Gurdon Institute, and leading UK centres in neurodegenerative diseases.

For more information, please visit our website, www.missiontherapeutics.com, or follow us on Twitter or LinkedIn.