Key Appointments Strengthen Mission Therapeutics’ Senior Management Team

CAMBRIDGE, UK– 4 August 2020 – Mission Therapeutics (“Mission”), a drug discovery and development company focused on selectively inhibiting deubiquitylating enzymes (DUBs), today announced the promotions of Dr Paul Thompson to CSO and Dr Nick Edmunds to CTO with immediate effect.

Dr Paul Thompson (CSO)

In his new role, Dr Thompson assumes responsibility for Mission’s discovery, validation and translational science activities, as well as biomarker research and target selection on novel DUBs.

Dr Thompson has ~18 years’ experience in translational research and early clinical development. He joined Mission as Medical Director for CNS in 2016, and in 2018 was promoted to Vice President of Clinical Development.

Previously, he has worked at ONO Pharma UK, where he was Clinical Science Director, and GlaxoSmithKline, where he led global project teams as Director of Discovery Medicine in Neurology, following earlier roles leading laboratory biomarker research and experimental medicine studies. Dr Thompson holds a PhD in Immuno- and Cell Biology from University College London and an MBiochem from the University of Oxford.

Dr Nick Edmunds (CTO)

Dr Edmunds assumes responsibility for Mission’s world-leading DUB platform and chemistry, in addition to exploratory toxicology and ADME activities.

With over 15 years’ pharmaceutical industry experience, Dr Edmunds has a track record in drug discovery and early clinical development. He joined Mission as a Senior Director in September 2018 from AstraZeneca and was promoted later that year to Vice President and Head of DUB Discovery.

At AstraZeneca Dr Edmunds held senior roles in Drug Safety and Metabolism, including Senior Director, Head of New Modalities and Director of Safety Pharmacology. Prior to that, he was a Research Fellow at Pfizer Global Research and Development, US, and the Cardiovascular Discipline Leader in Global Safety Pharmacology at Pfizer Global Research and Development, UK. Dr Edmunds holds a PhD from the Department of Pharmacology, University of Bath, and a BSc in Pharmacology from the University of Leeds.

Commenting on the appointments, Dr Anker Lundemose, CEO of Mission Therapeutics, said: “We are very pleased to be able to make these well-deserved promotions. Both Paul and Nick have already made substantial contributions to the advancement of Mission’s platform and pipeline. They will continue to play a pivotal role as the Company embarks upon the next exciting stage in its development, to continue progress of the AbbVie and Pfizer collaborations and bring our first-in-class USP30 inhibitor into the clinic.”

Dr Paul Thompson (left) and Dr Nick Edmunds (right). High-resolution images available on request.

 

FOR MORE INFORMATION:

Mission Therapeutics Ltd
Anker Lundemose MD PhD
Chief Executive Officer
Tel: +44 (0)1223 607 340

Instinctif Partners
Melanie Toyne-Sewell / Katie Duffell
Tel: +44 (0) 20 7457 2013
E: missiontherapeutics@instinctif.com

NOTES TO EDITORS:

About Mission Therapeutics

Mission Therapeutics is an early-stage drug development company targeting the ubiquitin pathway for the treatment of kidney disease, neurodegenerative disease, rare mitochondrial diseases and fibrosis. The Company has built a leading platform for the discovery and development of first-in-class, small molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging drug class that is attracting significant commercial interest in the area of protein homeostasis.

Mission has strong links with key academic and research centers, including Prof. Steve Jackson’s Cancer Research UK Laboratories at the University of Cambridge Gurdon Institute, and leading UK centres in neurodegenerative diseases. The Company also has secured major industry partnerships, including its collaboration with AbbVie in November 2018, for the research and preclinical development of specified DUB inhibitors for the treatment of Alzheimer’s Disease and Parkinson’s Disease. The Company is managed by a team with broad international, commercial and clinical-science experience.

To date the Company has received £73 million / $101 million in funding and its investors comprise blue chip institutional and corporate investors including: Pfizer Venture Investments, Sofinnova Partners, Roche Venture Fund, SR One, IP Group and Schroders Adveq. Mission Therapeutics was founded in 2011 and is based at the Babraham Research Campus, Cambridge, UK.

For more information, please visit our website, www.missiontherapeutics.com, or follow us on Twitter or LinkedIn.

Mission and Imperial College London Report Potent and Selective Probe for Deubiquitylating Enzyme UCHL1

LONDON AND CAMBRIDGE, UK – 7 July 2020 – Working in close collaboration, scientists from the Tate Group, Imperial College London, and drug discovery and development company, Mission Therapeutics (“Mission”), have discovered the first exquisitely selective probe for a deubiquitylating enzyme (DUB). The research has been published in the leading peer-reviewed Journal of the American Chemical Society (JACS).1

In this publication, Mission and the Tate Group report discovery of IMP-1710, a potent and selective activity-based probe for DUB UCHL1. Outstanding selectivity was demonstrated against a broad panel of other DUBs and confirmed through proteomic profiling. Such high quality, selective chemical probes can be powerful tools in unveiling novel biology and enabling research into new potential therapeutic targets.

With numerous links to disease pathologies, DUBs have attracted increasing interest as possible drug targets. DUBs are responsible for reversibly modifying proteins by removing ubiquitin ‘labels’. Over 100 human DUBs have been identified, expressed in many different cell types, with multiple different functions including regulating degradation of other proteins.

The UCHL1 DUB makes up over 1% of the protein mass of the human brain and is thought to play an important role in diseases including neurodegeneration, cancer and fibrosis. To-date, scientists have struggled to understand how UCHL1 works and how it drives disease because there is no effective inhibitor probe with which to study it.

As a selective UCHL1 probe, IMP-1710 provides researchers with the necessary tool to enable substantial progress in the field. In this study, the probe has already been used to inhibit and measure UCHL1 activity inside a range of cells for the first time. In cells from patients with idiopathic pulmonary fibrosis, IMP-1710 was shown to suppress activation of fibrosis pathways.

Commenting on the achievement, Prof. Edward Tate, Professor of Chemical Biology, Imperial College London, and Satellite Group Leader, Francis Crick Institute, said: “IMP-1710 represents a great leap forward both for UCHL1 research and for DUB programmes more broadly. Mission’s world-leading DUB platform has been fundamental to the success of the project. Together, we have reported the first potent and exquisitely selective activity-based probe for any DUB. This probe promises to unlock a new era of discovery for the important UCHL1 protein.”

Dr. Nick Edmunds, Vice President, Head of DUB Discovery at Mission, added: “This publication is the result of a long-term collaboration between Mission and Imperial. It is tremendous to report the research in such a high impact journal. This is a credit to the quality and significance of the science, as well as the dedication of the teams involved. The novel chemical probe will support and drive ongoing research towards treating fibrosis and other diseases with high unmet need.”

References
1. Panyain N, Godinat A, Lanyon-Hogg T, Lachiondo-Ortega S, Will EJ, Soudy C, Mondal M, Mason K, Elkhalifa S, Smith LM, Harrigan JA, and Tate EW. Discovery of a potent and selective covalent inhibitor and activity-based probe for the deubiquitylating enzyme UCHL1, with anti-fibrotic activity. J. Am. Chem. Soc., 2020;
https://doi.org/10.1021/jacs.0c04527/a>

– ENDS –

FOR MORE INFORMATION:

Mission Therapeutics Ltd
Anker Lundemose MD PhD
Chief Executive Officer
Tel: +44 (0)1223 607 340

Instinctif Partners
Melanie Toyne-Sewell / Katie Duffell
Tel: +44 (0) 20 7457 2013
missiontherapeutics@instinctif.com

NOTES TO EDITORS:

About Mission Therapeutics

Mission Therapeutics is an early-stage drug development company targeting the ubiquitin pathway for the treatment of kidney disease, neurodegenerative disease, rare mitochondrial diseases and fibrosis. The Company has built a leading platform for the discovery and development of first-in-class, small molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging drug class that is attracting significant commercial interest in the area of protein homeostasis.

Mission has strong links with key academic and research centers, including Prof. Steve Jackson’s Cancer Research UK Laboratories at the University of Cambridge Gurdon Institute, and leading UK centres in neurodegenerative diseases. The Company also has secured major industry partnerships, including its collaboration with AbbVie in November 2018 for the research and preclinical development of specified DUB inhibitors for the treatment of Alzheimer’s Disease and Parkinson’s Disease. The Company is managed by a team with broad international, commercial and clinical-science experience.

To date the Company has received £73 million / $101 million in funding. Its investors comprise blue chip institutional and corporate investors including: Pfizer Ventures, Sofinnova Partners, Roche Venture Fund, SR One, IP Group and Schroders Adveq. Mission Therapeutics was founded in 2011 and is based at the Babraham Research Campus, Cambridge, UK.

For more information, please visit our website, www.missiontherapeutics.com, or follow us on Twitter or LinkedIn.

About Imperial College London

Imperial College London is one of the world’s leading universities. The College’s 17,000 students and 8,000 staff are expanding the frontiers of knowledge in science, medicine, engineering and business, and translating their discoveries into benefits for our society.

Imperial is the UK’s most international university, according to Times Higher Education, with academic ties to more than 150 countries. Reuters named the College as the UK’s most innovative university because of its exceptional entrepreneurial culture and ties to industry.

www.imperial.ac.uk

For more information on the Tate Group, visit: www.imperial.ac.uk/tate-group

 

Mission Raises $15m and Expands its Relationship with Pfizer

CAMBRIDGE, UK– 6 July 2020 – Mission Therapeutics (“Mission”), a drug discovery and development company focused on selectively inhibiting deubiquitylating enzymes (DUBs), today announced that it has raised $15m (£12m) in equity investment. The round was led by existing investor Pfizer Ventures, the venture capital arm of Pfizer Inc. (“Pfizer”)(NYSE: PFE).

Mission and Pfizer Inc. have also expanded their relationship by entering into an evaluation and option agreement for DUB target validation.

Fund raising

Pfizer Ventures has been an investor in Mission Therapeutics since 2013. Today it made a further equity investment into the Company, contributing a super pro rata amount. All other existing investors within Mission joined the round on a pro rata basis. No further financial details have been disclosed.

The new capital will support development of Mission’s world-leading DUB platform, as well as growth of its pipeline of DUB inhibitor programmes.

Expansion of Pfizer collaboration

DUBs have attracted significant interest as potential drug targets. Playing an integral role in protein homeostasis, this large family of enzymes is involved in diverse cellular processes and many disease pathologies.

Under the terms of the evaluation and option agreement, Pfizer will access specific DUB inhibitors from Mission’s platform and test these compounds in phenotypic screens to validate promising drug targets. Pfizer will then have the option to negotiate target exclusivity for each of the DUBs of interest.

The agreement does not include any of Mission’s own lead DUB programs, such as USP30.

Commenting on the agreement, Dr. Denis Patrick, Managing Partner of Pfizer Ventures and Member of Mission’s Board of Directors, said:
“Since our initial investment in Mission seven years ago, the company has grown tremendously and the depth of its scientific expertise and capability has grown alongside it. We are proud to expand our relationship with the company and our scientists are looking forward to a successful collaboration in this important area of research.”

Dr. Anker Lundemose, CEO of Mission Therapeutics added:
“We are pleased to expand our relationship with Pfizer, one of the world’s premier biopharmaceutical companies. We have benefitted from the valuable contributions of Dr. Denis Patrick as a member of our Board of Directors and we look forward to working with the wider Pfizer team.”

– ENDS –

FOR MORE INFORMATION:

Mission Therapeutics Ltd
Anker Lundemose MD PhD
Chief Executive Officer
Tel: +44 (0)1223 607 340

Instinctif Partners
Melanie Toyne-Sewell / Katie Duffell
Tel: +44 (0) 20 7457 2013
missiontherapeutics@instinctif.com

NOTES TO EDITORS:

About Mission Therapeutics

Mission Therapeutics is an early-stage drug development company targeting the ubiquitin pathway for the treatment of kidney disease, neurodegenerative disease, rare mitochondrial diseases and fibrosis. The Company has built a leading platform for the discovery and development of first-in-class, small molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging drug class that is attracting significant commercial interest in the area of protein homeostasis.

Mission has strong links with key academic and research centers, including Prof. Steve Jackson’s Cancer Research UK Laboratories at the University of Cambridge Gurdon Institute, and leading UK centres in neurodegenerative diseases. The Company also has secured major industry partnerships, including its collaboration with AbbVie in November 2018, for the research and preclinical development of specified DUB inhibitors for the treatment of Alzheimer’s Disease and Parkinson’s Disease. The Company is managed by a team with broad international, commercial and clinical-science experience.

To date the Company has received £73 million / $101 million in funding. Its investors comprise blue chip institutional and corporate investors including: Pfizer Ventures, Sofinnova Partners, Roche Venture Fund, SR One, IP Group and Schroders Adveq. Mission Therapeutics was founded in 2011 and is based at the Babraham Research Campus, Cambridge, UK.

For more information, please visit our website, www.missiontherapeutics.com, or follow us on Twitter or LinkedIn.

Mission Moves to New Babraham Campus Headquarters

CAMBRIDGE, UK – 2 June 2020Mission Therapeutics (“Mission”), a drug discovery and development company focused on selectively inhibiting deubiquitylating enzymes (DUBs), today announces its move to new purpose-built headquarters on the Babraham Research Campus, Cambridge, UK.

Since its foundation in 2011, Mission has enjoyed significant success in building its world-leading DUB platform for the discovery and development of first-in-class, small molecule drugs. It has a thriving pipeline of programs in neurodegeneration, rare mitochondrial diseases, kidney disease and fibrosis, in-house and in partnership with a major biopharmaceutical company, AbbVie.

As the Company has grown, its need for space has increased and it has had to split its operations across two sites – at Granta Park and the Babraham Research Campus. Mission’s move into BioMed Realty’s newly developed Babraham Research Campus buildings will combine its two existing sites. This will bring all employees back together, promoting collaboration, innovation and efficiency, and will provide 40% more space to facilitate the Company’s continuing growth.

Mission anticipates completing the move of its offices and research laboratories into the new facility by 8 June 2020.

Commenting on the move, Dr. Anker Lundemose, Mission’s CEO said:
With Mission’s strong growth outlook, this move to a new, larger, united facility is key to our strategy. These headquarters will provide an inspiring work environment and support our culture of innovation and collaboration. We are happy to be staying on the Babraham Research Campus, which we have found offers an extraordinary ecosystem, with world-class research and business coming together.

On behalf of the management team, I would like to thank everyone, from both within and outside the Company, who has helped to execute this move so successfully. It has required a great feat of organisation, particularly during these unprecedented times under COVID-19 disruption. We are looking forward to all being together again.

– ENDS –

FOR MORE INFORMATION:

Mission Therapeutics Ltd
Anker Lundemose MD PhD
Chief Executive Officer
Tel: +44 (0)1223 607 340

Instinctif Partners
Melanie Toyne-Sewell / Katie Duffell
Tel: +44 (0) 20 7457 2013
missiontherapeutics@instinctif.com

NOTES TO EDITORS:

About Mission Therapeutics

Mission Therapeutics is an early-stage drug development company targeting the ubiquitin pathway for the treatment of kidney disease, neurodegenerative disease, rare mitochondrial diseases and fibrosis. The Company has built a leading platform for the discovery and development of first-in-class, small molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging drug class that is attracting significant commercial interest in the area of protein homeostasis.

Mission has strong links with key academic and research centers, including Prof. Steve Jackson’s Cancer Research UK Laboratories at the University of Cambridge Gurdon Institute, and leading UK centres in neurodegenerative diseases. The Company has also secured major industry partnerships, including its collaboration with AbbVie, which began in November 2018, for the research and preclinical development of specified DUB inhibitors for the treatment of Alzheimer’s Disease and Parkinson’s Disease. The Company is managed by a team with broad international, commercial and clinical-science experience.

To date, the Company has received £61 million ($86 million) in funding from blue chip institutional and corporate investors including: Pfizer Venture Investments, Sofinnova Partners, Roche Venture Fund, SR One, IP Group and Schroder Adveq. Mission Therapeutics was founded in 2011 and is based at the Babraham Research Campus, Cambridge, UK.

For more information, please visit our website, www.missiontherapeutics.com, or follow us on Twitter or LinkedIn.

Mission and AbbVie’s Collaboration in Alzheimer’s and Parkinson’s Diseases Reaches Milestone

CAMBRIDGE, UK – 3 December 2019 – Mission Therapeutics (“Mission”), a drug discovery and development company focused on selectively inhibiting deubiquitylating enzymes (DUBs), and AbbVie (“AbbVie”)(NYSE: ABBV), a global, research-driven biopharmaceutical company, today announced the identification of several DUBs as potential drug targets in their Alzheimer’s and Parkinson’s R&D collaboration.

AbbVie has nominated the panel of DUBs that will be progressed for further characterization and screening activities. This is the first major milestone of the Companies’ DUB research and preclinical development collaboration in neurodegenerative diseases.

Under the terms of the collaboration, announced in November 2018, Mission and AbbVie are working together to identify specific DUBs and discover suitable inhibitor compounds for the treatment of Alzheimer’s and Parkinson’s diseases. AbbVie then has the option to gain exclusive rights to develop and commercialize DUB inhibitors against up to four selected targets. Mission is eligible to receive success-based milestone payments and royalty payments for each commercialized product.

Over 50 million people worldwide are living with dementia and Alzheimer’s, and 10 million more with Parkinson’s. The diseases are associated with the accumulation of misfolded proteins, which are believed to cause impaired function and death of nerve cells in the brain. DUBs help to maintain healthy nerve cells by regulating the degradation of the toxic proteins. By modulating specific DUBs within the brain, AbbVie and Mission aim to develop drug candidates that enhance degradation of toxic proteins to treat these neurodegenerative disorders.

Commenting on the development, Dr. Anker Lundemose, Mission’s CEO said:

“Partnering with AbbVie has been a great experience and instrumental for our research. AbbVie brings expertise and capabilities complementary to our own, and it is a testament to all involved that we have reached this important milestone. We have made good progress to-date and our high-quality data has enabled AbbVie to take the decision to select multiple DUBs for further investigation. We look forward to continuing to work together to discover and develop DUB inhibitors towards the treatment of Alzheimer’s and Parkinson’s diseases.”

Dr. Eric Karran, Vice President, Discovery Neuroscience Research, AbbVie commented:

“The numbers of people living with Alzheimer’s and Parkinson’s is growing and there are currently no treatments capable of stopping or reversing either disease’s progression. This collaboration, using Mission’s DUB technology platform, shows promise for identifying potential drug targets and the development of new therapeutic options. We look forward to advancing our drug discovery programs with our Mission colleagues.”

 

In recognition of its significance and impact, the collaboration between Mission and AbbVie has been shortlisted for Scrip’s 2019 Best Partnership Alliance Award. The winner will be announced at the Scrip awards dinner on 4 December in London.

 

FOR MORE INFORMATION:

Mission Therapeutics Ltd

Anker Lundemose MD PhD

Chief Executive Officer

Tel: +44 (0)1223 607 340

 

Instinctif Partners

Melanie Toyne-Sewell / Katie Duffell

Tel: +44 (0) 20 7457 2013

missiontherapeutics@instinctif.com

 

NOTES TO EDITORS:

About Mission Therapeutics

Mission Therapeutics is an early-stage drug development company targeting the ubiquitin pathway for the treatment of kidney disease, neurodegenerative disease, rare mitochondrial diseases and fibrosis. The Company has built a leading platform for the discovery and development of first-in-class, small molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging drug class that is attracting significant commercial interest in the area of protein homeostasis.

 In November 2018, Mission Therapeutics and AbbVie entered into a collaboration in the research and preclinical development of specified DUB inhibitors for the treatment of Alzheimer’s Disease and Parkinson’s Disease. Mission has strong links with key academic and research centers, including Prof. Steve Jackson’s Cancer Research UK Laboratories at the University of Cambridge Gurdon Institute, and leading UK centres in neurodegenerative diseases. The Company is managed by a team with broad international, commercial and clinical-science experience.

In February 2016, the Company completed an $86m financing that was led by Imperial Innovations (now part of IP Group) and Woodford Patient Capital Trust and included participation from existing investors Sofinnova Partners, Roche Venture Fund, Pfizer Venture Investments and SR One. Mission Therapeutics was founded in 2011 and is based at the Babraham Research Campus, Cambridge, UK.

For more information, please visit our website, www.missiontherapeutics.com, or follow us on Twitter or LinkedIn.

 

 

 

BioMed Realty Announces First Lettings at Babraham Research Campus in Cambridge

Set to open in April 2020, the buildings are now more than 50% let or under offer, highlighting the thriving life science industry in Cambridge

Today, BioMed Realty, the leading provider of real estate solutions to the life science community, announced its two newly developed Babraham Research Buildings in Cambridge are more than 50% let or under offer, including leases to PetMedix Ltd and Mission Therapeutics Ltd.

In October 2017, BioMed Realty and Babraham Research Campus launched a partnership, creating 100,000 square foot of research space for growing bioscience-based companies seeking to scale up their operations. BioMed@Babraham encompasses two adjacent buildings and the new facilities will provide a corporate campus feel to further promote innovation and strengthen links between academia and the commercial world. This project represents a £42 million investment in the Campus by BioMed Realty.

Colleen O’Connor, BioMed Realty’s Senior Director for the UK Market commented: “The Babraham Research Campus has been at the forefront of supporting scale-ups. BioMed@Babraham furthers this effort and offers growing life science companies access to first-class fitted lab and office space within the thriving Babraham Research Campus, which is already home to over 60 research organizations. We are excited to be moving forward on final fit-out construction for all suites, with tenants occupying as early as April 2020.”

As a sector at the cutting edge of science, the leaders of UK life sciences have continued working hard to raise capital for their R&D programmes. The UK BioIndustry Association (BIA) and Informa Pharma Intelligence have released a report showing £182 million was raised by private biotech companies between December 2018 and the end of February 2019, almost £50 million more than during the same period a year earlier.

Dr. Tom Weaver, CEO of PetMedix™ commented: “One of the real strengths of Cambridge for the biotech industry is its ability to both attract large companies and foster the growth of new ones. The ecosystem of academic research, thriving companies, and a highly skilled talent pool make it a perfect place to start and build a company. This success can make it challenging for companies like ours to secure the necessary space to grow in the current competitive commercial environment. PetMedix is entering a growth and expansion phase as we look to bring the power of antibody therapeutics to animal health, and this comes with a need to scale our physical footprint. We are tremendously excited to be one of the first two companies to move into BioMed Reality’s brand new, purpose-built premises on the renowned Babraham campus. BioMed has recognised the clear need for developments of this size and composition, and we are looking forward to establishing PetMedix at this new site and engaging with the vibrant research and development ecosystem of like-minded companies, both at Babraham and in the surrounding Cambridge cluster.

Michael Jones, Director and Head of Commercial Division for Cheffins Commercial commented: “Life Sciences in the UK continues to thrive, particularly the Cambridge cluster. Babraham offers a rare opportunity to lease new construction with purpose-built life science lab and office space in high-quality buildings. It’s not surprising there is tremendous interest.”

The sector currently contributes over £70 billion to the UK economy and provides jobs for almost 241,000 people across the country. According to data from business intelligence specialist, Vacancysoft, demand for professionals to work within the UK’s Life Sciences sector increased by 11% in 2018 – clinical vacancies rose the highest, with an increase of 37%, and demand for research and development professionals rose by 4.6%.

Dr Anker Lundemose, CEO of Mission Therapeutics added: “Fuelled by its established academic community and growing private sector, Cambridge has a strong science culture, which celebrates entrepreneurship and collaboration. As Mission has prospered and grown over the past seven years, we were forced to split the Company over two sites. The development of these new buildings by BioMed Realty at the Babraham Research Campus present us with the exciting opportunity to bring all our employees together again on one site, to facilitate open collaboration, improve efficiency and promote innovation in the field of mitochondrial diseases, fibrosis and neurodegenerative disorders.

BioMed Realty entered the Cambridge, UK market with the acquisition of Granta Park in 2012. As part of its continued growth in Cambridge, BioMed Realty formed a collaborative partnership with Babraham Bioscience Technologies in 2017 to build two new buildings on the Babraham Research Campus. Upon completion, the Babraham Research Campus project will bring BioMed Realty’s total presence in Cambridge to almost 900,000 square feet. The addition of BioMed Realty to the Babraham Research Campus supports the Biotechnology and Biological Sciences Research Council’s campus development strategy.

For more information on lettings and the remaining space, please contact Michael Jones, from Cheffins (01223 271971) who are letting agents on behalf of BioMed.

 

– ENDS –

About BioMed Realty
Founded in 2004, and a Blackstone portfolio company since 2016, BioMed Realty owns and operates high-quality life science real estate comprising 11 million square feet located in the leading innovation markets throughout the United States and United Kingdom, led by Boston-Cambridge, San Francisco, San Diego, Seattle, New York and Cambridge U.K. In addition, BioMed Realty maintains a premier development pipeline with two million square feet of Class A properties in active construction to meet the growing demand of the life science industry. With over 200 tenant partners, BioMed Realty provides real estate solutions for global enterprises, established biotechnology and innovation companies, leading universities and premier research institutions. Follow us on Twitter @biomedrealty.

About PetMedix™
PetMedix™ is a Cambridge, UK based research and development stage biopharmaceutical company developing antibody-based therapeutics for companion animals. The growing team have over 30 years’ experience building platforms that can develop species-specific therapeutic antibodies. Driven by the core value of improving the health and welfare of animals, PetMedix™ is taking the cutting edge of human medicine and using it to develop innovative new veterinary treatments against a wide range of clinical indications for dogs and for cats.
Website: https://www.petmedix.co.uk
Twitter: @PetMedix, LinkedIn: PetMedix, Facebook: @PetMedix, Instagram: @PetMedix

About Mission Therapeutics
Mission Therapeutics is an early-stage drug development company targeting the ubiquitin pathway for the treatment of kidney disease, neurodegenerative disease, rare mitochondrial diseases and fibrosis. The Company has built a leading platform for the discovery and development of first-in-class, small molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging drug class that is attracting significant commercial interest in the area of protein homeostasis. Mission has a collaboration in the research and preclinical development of specified DUB inhibitors for the treatment of Alzheimer’s Disease and Parkinson’s Disease. It also has strong links with academic and research centres, such as Prof. Steve Jackson’s Cancer Research UK Laboratories at the University of Cambridge Gurdon Institute, and leading UK centres in neurodegenerative diseases.

For more information, please visit our website, www.missiontherapeutics.com, or follow us on Twitter or LinkedIn.

Mission Therapeutics’ Collaboration with AbbVie Nominated for Scrip Best Partnership Alliance Award

CAMBRIDGE, UK – 16 September 2019 – Mission Therapeutics (“Mission”), a drug discovery and development company focused on selectively inhibiting deubiquitylating enzymes (DUBs), announced today that its collaboration with research-based global biopharmaceutical company, AbbVie (“AbbVie”)(NYSE: ABBV), has been shortlisted for the 2019 Scrip Best Partnership Alliance Award.

Mission and AbbVie are working together in the research and preclinical development of DUB inhibitors for the treatment of Alzheimer’s and Parkinson’s diseases. As the most common forms of neurological disorder, over 50 million people worldwide are living with dementia and Alzheimer’s, and 10 million more with Parkinson’s.

Under the terms of the agreement, the Companies will collaborate to identify specific DUBs of interest and discover suitable inhibitor compounds. AbbVie will then have the option to gain exclusive rights to develop and commercialise compounds against up to four selected targets.

Dr. Anker Lundemose, Chief Executive Officer at Mission, commented:

“It is an honour that our collaboration with AbbVie has been selected as a finalist for the Best Partnership Alliance Award by the expert panel. Partnering with AbbVie has been instrumental for our research and we are pleased that our work with them is being recognised within the industry. We look forward to attending the ceremony and celebrating the huge progress that has been made across the pharmaceutical and biotech industries this year.”

The winners of the 2019 Scrip Awards will be announced at the awards dinner on 4 December in London.

  

FOR MORE INFORMATION:

Mission Therapeutics Ltd

Anker Lundemose MD PhD

Chief Executive Officer

T: +44 (0) 1223 607340

 

Instinctif Partners

Melanie Toyne-Sewell / Eileen Paul

T: +44 (0) 20 7457 2020

E: missiontherapeutics@instinctif.com

 NOTES TO EDITORS:

About Mission Therapeutics

Mission Therapeutics is an early-stage drug development company targeting the ubiquitin pathway for the treatment of neurodegenerative disease, rare mitochondrial diseases and fibrosis. The Company has built a leading platform for the discovery and development of first-in-class, small molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging drug class that is attracting significant commercial interest in the area of protein homeostasis.

In November 2018, Mission Therapeutics and AbbVie entered into a collaboration in the research and preclinical development of specified DUB inhibitors for the treatment of Alzheimer’s Disease and Parkinson’s Disease. Mission has strong links with key academic and research centers, including Prof. Steve Jackson’s Cancer Research UK Laboratories at the University of Cambridge Gurdon Institute, and leading UK centres in neurodegenerative diseases. The Company is managed by a team with broad international, commercial and clinical-science experience.

In February 2016, the Company completed an $86m financing that was led by Imperial Innovations (now part of IP Group) and Woodford Patient Capital Trust and included participation from existing investors Sofinnova Partners, Roche Venture Fund, Pfizer Venture Investments and SR One. Mission Therapeutics was founded in 2011 and is based at the Babraham Research Campus, Cambridge, UK.

For more information, please visit our website, www.missiontherapeutics.com, or follow us on Twitter or LinkedIn.

Dr. James Summers Appointed to Mission Therapeutics’ Board of Directors

CAMBRIDGE, UK – 1 May 2019 – Mission Therapeutics (“Mission”), a drug discovery and development company focused on treating mitochondrial diseases, fibrosis and neurodegenerative disorders by selectively inhibiting deubiquitylating enzymes (DUBs), today announced the appointment of Dr. James Summers as an independent member to its Board of Directors, with immediate effect.

Dr. Summers brings over 30 years of drug discovery and pharmaceutical research management experience to Mission’s Board. His most recent position was as Vice President of Neuroscience Research at AbbVie, where he led drug discovery efforts in the treatment of Alzheimer’s and Parkinson’s diseases, pain, and psychiatric disorders.

Dr. Colin Goddard, Non-Executive Chairman of the Board of Directors at Mission, said:

“We are pleased to welcome Dr. Summers to our Board of Directors. Jim has spearheaded numerous transactions for AbbVie in the area of neurological disorders, including Mission’s collaboration with AbbVie for the development of DUB inhibitors to treat Alzheimer’s and Parkinson’s diseases. We believe his appointment as a Director will bring immense domain knowledge to our deliberations as a board and I look forward to working with him in his new role.”

Dr. Anker Lundemose, Chief Executive Officer at Mission, added:

Since the start of the AbbVie collaboration in November 2018, the Mission team has already benefited from the strength of Jim’s specialist knowledge and sector experience. We believe that he will be of tremendous value to the Company as we continue to progress our therapeutic pipeline”.

Dr. James Summers, newly appointed Non-Executive Director at Mission, also commented:

“In addition to its best-in-class DUB technology platform, Mission has researchers with a unique understanding of the science behind Alzheimer’s and Parkinson’s diseases. I am thrilled to have the opportunity to continue to support the Company as it works towards developing new treatments that positively impact the lives of patients with these debilitating diseases.”

Prior to his role at AbbVie, Dr. Summers was Divisional Vice President of Advanced Technology with Abbott, where he managed the organisation responsible for the diverse technologies and services that enable effective drug discovery research across the company. He has established new research sites in Cambridge, Massachusetts and Shanghai, China and led the way in refocusing the research strategies of this global organisation. He has also championed multiple successful deals, collaborations and investments and advanced more than 20 compounds into clinical development.

Dr. Summers earned his Bachelor of Science degree, summa cum laude, in chemistry from Denison University and his doctorate in organic chemistry from Harvard University.

 

FOR MORE INFORMATION:

Mission Therapeutics Ltd

Anker Lundemose MD PhD

Chief Executive Officer

T: +44 (0) 1223 607340

 

Instinctif Partners

Melanie Toyne-Sewell / Eileen Paul

T: +44 (0) 20 7457 2020

E: missiontherapeutics@instinctif.com

 

 

NOTES TO EDITORS:

About Mission Therapeutics

Mission Therapeutics is an early-stage drug development company targeting the ubiquitin pathway for the treatment of neurodegenerative disease, rare mitochondrial diseases and fibrosis. The Company has built a leading platform for the discovery and development of first-in-class, small molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging drug class that is attracting significant commercial interest in the area of protein homeostasis.

 In November 2018, Mission Therapeutics and AbbVie entered into a collaboration in the research and preclinical development of specified DUB inhibitors for the treatment of Alzheimer’s Disease and Parkinson’s Disease. Mission has strong links with key academic and research centers, including Prof. Jackson’s Cancer Research UK Laboratories at the University of Cambridge Gurdon Institute, and leading UK centres in neurodegenerative diseases. The Company is managed by a team with broad international, commercial and clinical-science experience.

In February 2016, the Company completed an $86m financing that was led by Imperial Innovations (now part of IP Group) and Woodford Patient Capital Trust and included participation from existing investors Sofinnova Partners, Roche Venture Fund, Pfizer Venture Investments and SR One. Mission Therapeutics was founded in 2011 and is based at the Babraham Research Campus, Cambridge, UK.

For more information, please visit our website, www.missiontherapeutics.com, or follow us on Twitter or LinkedIn.

Mission Therapeutics to Present at the Cowen and Company 39th Annual Healthcare Conference

CAMBRIDGE, UK – 6th March 2019 –Mission Therapeutics, a drug discovery and development company focused on treating mitochondrial diseases, fibrosis and neurodegenerative disorders by selectively inhibiting deubiquitylating enzymes (DUBs), announced today that Dr Anker Lundemose, CEO, will present a company overview at the Cowen and Company 39th Annual Healthcare Conference, in Boston, Massachusetts.

The presentation will take place on Tuesday 12th March at 8.00 am ET.

ENDS

FOR MORE INFORMATION:

Mission Therapeutics Ltd
Anker Lundemose MD PhD
Chief Executive Officer
Tel: +44 (0) 1223 607340
Instinctif Partners
Melanie Toyne-Sewell / Eileen Paul
Tel: +44 (0) 20 7457 2020
missiontherapeutics@instinctif.com

NOTES TO EDITORS:

About Mission Therapeutics

Mission Therapeutics is an early-stage drug development company targeting the ubiquitin pathway for the treatment of neurodegenerative disease, rare mitochondrial diseases and fibrosis. The Company has built a leading platform for the discovery and development of first-in-class, small-molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging drug class that is attracting significant commercial interest in the area of protein homeostasis.

In November 2018, Mission Therapeutics and AbbVie entered into a collaboration in the research and preclinical development of specified DUB inhibitors for the treatment of Alzheimer’s Disease and Parkinson’s Disease. Mission has strong links with key academic and research centers, including Prof. Jackson’s Cancer Research UK Laboratories at the University of Cambridge Gurdon Institute, and leading UK centres in neurodegenerative diseases. The Company is managed by a team with broad international, commercial and clinical-science experience.

In February 2016, the Company completed a £60m financing that was led by Imperial Innovations (now part of IP Group) and Woodford Patient Capital Trust and included participation from existing investors Sofinnova Partners, Roche Venture Fund, Pfizer Venture Investments and SR One. Mission Therapeutics was founded in 2011 and is based at the Babraham Research Campus, Cambridge, UK.

Dr Nick Edmunds Appointed to VP, Head of DUB Discovery

CAMBRIDGE, UK – 3 December 2018 –Mission Therapeutics, a drug discovery and development company focused on treating mitochondrial diseases, fibrosis and neurodegenerative disorders by selectively inhibiting deubiquitylating enzymes (DUBs), has appointed Dr Nick Edmunds as Vice President, Head of DUB Discovery, with immediate effect.

Dr Edmunds has over 15 years’ pharmaceutical industry experience and a track record of delivery across small molecule preclinical drug discovery and early clinical development. He joined Mission as a Senior Director in September from AstraZeneca, where he had previously held a number of senior roles in Drug Safety and Metabolism, including Senior Director, Head of New Modalities and Director of Safety Pharmacology.

Prior to that, he was a Research Fellow at Pfizer Global Research and Development, Groton, USA and the Cardiovascular Discipline Leader in Global Safety Pharmacology at Pfizer Global Research and Development, Sandwich, UK.  Dr Edmunds carried out his postdoctoral research studies in the Department of Physiology, University of Birmingham, UK. He also holds a PhD from the Pharmacy and Pharmacology Department, University of Bath, UK and a BSc in Pharmacology from the University of Leeds, UK.

Dr Anker Lundemose, Mission’s CEO, said:

“I am very pleased to welcome Nick to Mission Therapeutics’ Management team, especially at this exciting time following the announcement of a major collaboration with AbbVie. Nick has the right skills, experience, enthusiasm and mindset to provide superb leadership to our research team and to advance our discovery DUB programmes.”

His internal appointment follows Dr Anne Phelan’s decision to step down as Executive Vice President of Research.

Dr Anker Lundemose, added:

“I would like to thank Anne for providing excellent leadership to our research team. We will miss her and wish her all the very best with her future endeavours.”

Dr Nick Edmunds, newly appointed, Vice President, Head of DUB Discovery at Mission Therapeutics, said:

“Mission has been leading the way with its research in the DUBs field and so I am really looking forward to being part of the management team. The potential of the in-house programmes as well as the recent collaboration with AbbVie make this an exciting time to help take the Company forward.”

 

FOR MORE INFORMATION:

Mission Therapeutics Ltd

Anker Lundemose MD PhD

Chief Executive Officer

Tel: +44 (0) 1223 607340

 

Instinctif Partners

Melanie Toyne-Sewell / Eileen Paul

Tel: +44 (0) 20 7457 2020

missiontherapeutics@instinctif.com

 

 

 

NOTES TO EDITORS:

About Mission Therapeutics

Mission Therapeutics is an early-stage drug development company targeting the ubiquitin pathway for the treatment of neurodegenerative disease, rare mitochondrial diseases, and fibrosis. The Company has built a leading platform for the discovery and development of first-in-class, small-molecule drugs that selectively target deubiquitylating enzymes (DUBs) – an emerging drug class that is attracting significant commercial interest in the area of protein homeostasis.

In November 2018 Mission Therapeutics and AbbVie entered into a collaboration in the research and preclinical development of specified DUB inhibitors for the treatment of Alzheimer’s Disease and Parkinson’s Disease. Mission has strong links with key academic and research centers, including Prof. Jackson’s Cancer Research UK Laboratories at the University of Cambridge Gurdon Institute, and leading UK centres in neurodegenerative diseases. The Company is managed by a team with broad international, commercial and clinical-science experience.

In February 2016, the Company completed an $86m financing that was led by Imperial Innovations (now part of IP Group) and Woodford Patient Capital Trust and included participation from existing investors Sofinnova Partners, Roche Venture Fund, Pfizer Venture Investments and SR One. Mission Therapeutics was founded in 2011 and is based at the Babraham Research Campus, Cambridge, UK.