2023

Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson’s disease mouse model Nature Communications (November 2023)

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2020

Developing new treatments in partnership for primary mitochondrial disease: What does industry need from academics, and what do academics need from industry? Journal of Inherited Metabolic Disease (November 2020)

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Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity: Journal of the American Chemical Society (June 2020)

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2017

Deubiquitylating enzymes and drug discovery: emerging opportunities: Nature Reviews Drug Discovery (2017)

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2016

Activity Based Profiling of Deubiquitylating Enzymes and Inhibitors in Animal Tissues: Methods in Molecular Biology (Clifton, N.J.), 2016

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Monitoring Target Engagement of Deubiquitylating Enzymes Using Activity Probes: Past, Present, and Future: Methods in Molecular Biology (Clifton, N.J.), 2016

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Recent Advances in the Discovery of Deubiquitinating Enzyme Inhibitors: Progress in Medicinal Chemistry, 2016

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2015

USP4 Auto-Deubiquitylation Promotes Homologous Recombination: Molecular Cell, October 2015

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2014

Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity: Nature Cell Biology, October 2014

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2013

Deubiquitylating Enzymes and DNA Damage Response Pathways: Cell Biochemistry and Biophysics, May 2013

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Regulation of DNA damage responses by ubiquitin and SUMO: Molecular Cell, March 2013

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2009

The DNA Damage Response in Human Biology and Disease: Nature, October 2009

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The Path to Progress: Niall Martin and Xavier Jacq (MISSION Therapeutics)